The Role of Calcium in Augmenting the Efficacy of Primary Homeostasis after Hemorrhagic Shock

Background: Traumatic Hemorrhagic Shock (THS) causes hypocalcemia (Ca). This study assesses how low Ca affects platelet (Plt) function. Study Design: A research registry was queried for 555 studies on 341 patients (pts) with THS requiring 14.2 units RBC, 8.4 FFP, 3.6 Plt, and 18.9 mEq by end of O.R. (7.3 hours). Factors analyzed included Plt count, Ca, Bleeding Time (BT), aggregation ADP (PAadp) collagen (PAcol), including Max PA, T1/2 rate plus release factors, beta thromboglobulin (BTG) PF-4. Studies were made in (26 pts) during fluid uptake phase II at 29 hours (216 pts), mobilization III 56 (283 as outpatients (30 pts). Results: caused Plts (1x10 SD) O.R (107 ± 43), (96 35), (105 59) (1.6 0.3), (1.8 0.2), (2.1 0.2). Low correlated (p=<0.05) PAadp PAcol O.R., II, III. directly aggregation, BTG PF-4, inversely BT. All outpatient normal. Conclusion: which leads to impaired Routine supplementation is recommended THS.